An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice

Progressive hearing loss is common in the human population, but little is known about the molecular basis. We report a new ENU-induced mouse mutant, diminuendo, with a single base change in the seed region of Mirn96. Heterozygotes show progressive loss of hearing and hair cell anomalies, while homoz...

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Detalhes bibliográficos
Main Authors: Lewis, Morag A, Quint, Elizabeth, Glazier, Anne M, Fuchs, Helmut, De Angelis, Martin Hrabé, Langford, Cordelia, van Dongen, Stijn, Abreu-Goodger, Cei, Piipari, Matias, Redshaw, Nick, Dalmay, Tamas, Pelayo, Miguel Angel Moreno, Enright, Anton J, Steel, Karen P
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705913/
https://ncbi.nlm.nih.gov/pubmed/19363478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.369
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