Variola Virus Topoisomerase: DNA Cleavage Specificity and Distribution of Sites in Poxvirus Genomes

Topoisomerase enzymes regulate superhelical tension in DNA resulting from transcription, replication, repair, and other molecular transactions. Poxviruses encode an unusual type IB topoisomerase that acts only at conserved DNA sequences containing the core pentanucleotide 5′-(T/C)CCTT-3′. In X-ray s...

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Autors principals: Minkah, Nana, Hwang, Young, Perry, Kay, Van Duyne, Gregory D., Hendrick, Robert Curtis, Lefkowitz, Elliot J., Hannenhalli, Sridhar, Bushman, Frederic D.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705903/
https://ncbi.nlm.nih.gov/pubmed/17462694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.02.037
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