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Aberrant Trafficking of Human Melanocortin 1 Receptor Variants Associated with Red Hair and Skin Cancer. Steady State Retention of Mutant Forms in the Proximal Golgi
The melanocortin 1 receptor (MC1R), a Gs protein-coupled receptor (GPCR) expressed in melanocytes, is a major determinant of skin pigmentation and phototype. MC1R activation stimulates melanogenesis and increases the ratio of black, strongly photoprotective eumelanins to reddish, poorly photoprotect...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2705480/ https://ncbi.nlm.nih.gov/pubmed/19452503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21804 |
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