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High-Level Biosynthesis of the Anteiso-C(17) Isoform of the Antibiotic Mycosubtilin in Bacillus subtilis and Characterization of Its Candidacidal Activity
High-level production (880 mg liter(−1)) and isolation of the anteiso-C(17) isoform of the lipopeptide mycosubtilin produced by a genetically engineered Bacillus subtilis strain are reported. Antifungal activity of this isoform, as determined via culture and fluorometric and cell leakage assays, sug...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2704807/ https://ncbi.nlm.nih.gov/pubmed/19429561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00548-09 |
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