Variation in Antagonism of the Interferon Response to Rotavirus NSP1 Results in Differential Infectivity in Mouse Embryonic Fibroblasts

Rotavirus NSP1 has been shown to function as an E3 ubiquitin ligase that mediates proteasome-dependent degradation of interferon (IFN) regulatory factors (IRF), including IRF3, -5, and -7, and suppresses the cellular type I IFN response. However, the effect of rotavirus NSP1 on viral replication is...

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Detaylı Bibliyografya
Asıl Yazarlar: Feng, N., Sen, A., Nguyen, H., Vo, P., Hoshino, Y., Deal, E. M., Greenberg, H. B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2009
Konular:
Pathogenesis and Immunity
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704795/
https://ncbi.nlm.nih.gov/pubmed/19420080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00585-09
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