Elucidating and Minimizing the Loss by Recombinant Vaccinia Virus of Human Immunodeficiency Virus Gene Expression Resulting from Spontaneous Mutations and Positive Selection

While characterizing modified vaccinia virus recombinants (rMVAs) containing human immunodeficiency virus env and gag-pol genes, we detected nonexpressing mutants by immunostaining individual plaques. In many cases, the numbers of mutants increased during successive passages, indicating strong selec...

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Bibliografiske detaljer
Main Authors: Wyatt, Linda S., Earl, Patricia L., Xiao, Wei, Americo, Jeffrey L., Cotter, Catherine A., Vogt, Jennifer, Moss, Bernard
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Genome Replication and Regulation of Viral Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704791/
https://ncbi.nlm.nih.gov/pubmed/19420086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00687-09
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