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Early Upregulation of Acute Respiratory Distress Syndrome-Associated Cytokines Promotes Lethal Disease in an Aged-Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Infection

Several respiratory viruses, including influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV), produce more severe disease in the elderly, yet the molecular mechanisms governing age-related susceptibility remain poorly studied. Advanced age was significantly associated with inc...

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Autori principali: Rockx, Barry, Baas, Tracey, Zornetzer, Gregory A., Haagmans, Bart, Sheahan, Timothy, Frieman, Matthew, Dyer, Matthew D., Teal, Thomas H., Proll, Sean, van den Brand, Judith, Baric, Ralph, Katze, Michael G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704758/
https://ncbi.nlm.nih.gov/pubmed/19420084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00127-09
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