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The Age-Associated Decline of Glycogen Synthase Kinase 3β Plays a Critical Role in the Inhibition of Liver Regeneration

Aging reduces the regenerative capacities of many tissues. In this paper, we show a critical role of the glycogen synthase kinase 3β (GSK3β)-cyclin D3 pathway in the loss of the regenerative capacity of the liver. In young animals, high levels of growth hormone (GH) increase expression of GSK3β, whi...

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Autores principales: Jin, Jingling, Wang, Guo-Li, Shi, Xiurong, Darlington, Gretchen J., Timchenko, Nikolai A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704742/
https://ncbi.nlm.nih.gov/pubmed/19398579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00456-09
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