Novel Anion Liposome-Encapsulated Antisense Oligonucleotide Restores Susceptibility of Methicillin-Resistant Staphylococcus aureus and Rescues Mice from Lethal Sepsis by Targeting mecA

β-Lactam resistance in methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) is caused by the production of an additional low-affinity penicillin-binding protein 2a, which is encoded by the mecA gene. The disruption of mecA may inhibit mecA expression and thereafter lead to the restoration...

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Detalhes bibliográficos
Main Authors: Meng, Jingru, Wang, Hui, Hou, Zheng, Chen, Tao, Fu, Jingguo, Ma, Xue, He, Gonghao, Xue, Xiaoyan, Jia, Min, Luo, Xiaoxing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704696/
https://ncbi.nlm.nih.gov/pubmed/19433567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01542-08
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