Combination of Daptomycin plus Ceftriaxone Is More Active than Vancomycin plus Ceftriaxone in Experimental Meningitis after Addition of Dexamethasone

We examined the cerebrospinal fluid penetration of daptomycin after the addition of dexamethasone and its bactericidal efficacy with and without ceftriaxone in an experimental rabbit model of pneumococcal meningitis. The combination of daptomycin with ceftriaxone was the most efficacious regimen for...

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Autores principales: Egermann, U., Stanga, Z., Ramin, A., Acosta, F., Stucki, A., Gerber, P., Cottagnoud, M., Cottagnoud, P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704679/
https://ncbi.nlm.nih.gov/pubmed/19364870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00952-08
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