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Modeling the Autoinhibition of Clarithromycin Metabolism during Repeated Oral Administration
Clarithromycin decreases CYP3A4 activity and thus gradually inhibits its own metabolism as well as that of coadministered drugs. The aim of this study was to obtain an understanding of the time course of these changes. The plasma concentration-time profiles of clarithromycin and its active metabolit...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology (ASM)
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2704653/ https://ncbi.nlm.nih.gov/pubmed/19414584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01193-08 |
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