Loading...

Modeling the Autoinhibition of Clarithromycin Metabolism during Repeated Oral Administration

Clarithromycin decreases CYP3A4 activity and thus gradually inhibits its own metabolism as well as that of coadministered drugs. The aim of this study was to obtain an understanding of the time course of these changes. The plasma concentration-time profiles of clarithromycin and its active metabolit...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Abduljalil, Khaled, Kinzig, Martina, Bulitta, Jürgen, Horkovics-Kovats, Stefan, Sörgel, Fritz, Rodamer, Michael, Fuhr, Uwe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704653/
https://ncbi.nlm.nih.gov/pubmed/19414584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01193-08
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!