Reduced Susceptibility to Cefepime among Escherichia coli Clinical Isolates Producing Novel Variants of CMY-2 β-Lactamase

Here we describe three Escherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of the bla(CMY) genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in th...

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Bibliografiske detaljer
Main Authors: Doi, Yohei, Paterson, David L., Adams-Haduch, Jennifer M., Sidjabat, Hanna E., O'Keefe, Alexandra, Endimiani, Andrea, Bonomo, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704647/
https://ncbi.nlm.nih.gov/pubmed/19414578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00133-09
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