HIV Protease Inhibitor Lopinavir-induced TNF-a and IL-6 Expression is Coupled to the Unfolded Protein Response and ERK Signaling Pathways in Macrophages

HIV Protease inhibitor (PI)-associated cardiovascular risk, especially atherosclerosis, has become a major concern in the clinic. Macrophages are key players in the inflammatory response and atherosclerosis formation. We have previously shown that HIV PIs induce endoplasmic reticulum (ER) stress, ac...

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Detalhes bibliográficos
Main Authors: Chen, Li, Jarujaron, Sirikalaya, Wu, Xudong, Sun, Lixin, Zha, Weibin, Liang, Guang, Gurley, Emily C., Studer, Elaine J., Hylemon, Phillip B., Pandak, William M., Zhang, Luyong, Wang, Guangji, Li, Xiaokun, Dent, Paul, Zhou, Huiping
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704357/
https://ncbi.nlm.nih.gov/pubmed/19447225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.03.022
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