The effect of the cyclin-dependent kinase inhibitor flavopiridol on anaplastic large cell lymphoma cells and relationship with NPM-ALK kinase expression and activity

BACKGROUND: The loss of cell cycle regulation due to abnormal function of cyclin-dependent kinases (cdk) occurs in tumors and leads to genetic instability of chemotherapy-resistant cells. In this study, we investigated the effect of the cdk inhibitor flavopiridol in anaplastic large cell lymphomas,...

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Bibliographic Details
Main Authors: Bonvini, Paolo, Zorzi, Elisa, Mussolin, Lara, Monaco, Giovanni, Pigazzi, Martina, Basso, Giuseppe, Rosolen, Angelo
Format: Artigo
Language:Inglês
Published: Ferrata Storti Foundation 2009
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704305/
https://ncbi.nlm.nih.gov/pubmed/19535344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2008.004861
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