RhoA-ROCK signaling is involved in contraction-mediated inhibition of SERCA2a expression in cardiomyocytes

In neonatal ventricular cardiomyocytes (NVCM), decreased contractile activity stimulates sarco-endoplasmic reticulum Ca(2+)-ATPase2a (SERCA2a), analogous to reduced myocardial load in vivo. This study investigated in contracting NVCM the role of load-dependent RhoA-ROCK signaling in SERCA2a regulati...

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Main Authors: Vlasblom, Ronald, Muller, Alice, Beckers, Cora M. L., van Nieuw Amerongen, Geerten P., Zuidwijk, Marian J., van Hardeveld, Cornelis, Paulus, Walter J., Simonides, Warner S.
Format: Artigo
Jezik:Inglês
Izdano: Springer-Verlag 2009
Teme:
Signaling and Cell Physiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704291/
https://ncbi.nlm.nih.gov/pubmed/19294414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-009-0659-x
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