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Mutations in the U5 snRNA result in altered splicing of subsets of pre-mRNAs and reduced stability of Prp8
The U5 snRNA loop 1 aligns the 5′ and 3′ exons for ligation during the second step of pre-mRNA splicing. U5 is intimately associated with Prp8, which mediates pre-mRNA repositioning within the catalytic core of the spliceosome and interacts directly with U5 loop 1. The genome-wide effect of three U5...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2704078/ https://ncbi.nlm.nih.gov/pubmed/19447917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1347409 |
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