The Heme Biosynthetic Pathway of the Obligate Wolbachia Endosymbiont of Brugia malayi as a Potential Anti-filarial Drug Target

BACKGROUND: Filarial parasites (e.g., Brugia malayi, Onchocerca volvulus, and Wuchereria bancrofti) are causative agents of lymphatic filariasis and onchocerciasis, which are among the most disabling of neglected tropical diseases. There is an urgent need to develop macro-filaricidal drugs, as curre...

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Bibliographic Details
Main Authors: Wu, Bo, Novelli, Jacopo, Foster, Jeremy, Vaisvila, Romualdas, Conway, Leslie, Ingram, Jessica, Ganatra, Mehul, Rao, Anita U., Hamza, Iqbal, Slatko, Barton
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703803/
https://ncbi.nlm.nih.gov/pubmed/19597542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000475
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