Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit...

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Main Authors: Ferreira, Manuel A R, O’Donovan, Michael C, Meng, Yan A, Jones, Ian R, Ruderfer, Douglas M, Jones, Lisa, Fan, Jinbo, Kirov, George, Perlis, Roy H, Green, Elaine K, Smoller, Jordan W, Grozeva, Detelina, Stone, Jennifer, Nikolov, Ivan, Chambert, Kimberly, Hamshere, Marian L, Nimgaonkar, Vishwajit L, Moskvina, Valentina, Thase, Michael E, Caesar, Sian, Sachs, Gary S, Franklin, Jennifer, Gordon-Smith, Katherine, Ardlie, Kristin G, Gabriel, Stacey B, Fraser, Christine, Blumenstiel, Brendan, Defelice, Matthew, Breen, Gerome, Gill, Michael, Morris, Derek W, Elkin, Amanda, Muir, Walter J, McGhee, Kevin A, Williamson, Richard, MacIntyre, Donald J, MacLean, Alan W, Clair, David St, Robinson, Michelle, Van Beck, Margaret, Pereira, Ana C P, Kandaswamy, Radhika, McQuillin, Andrew, Collier, David A, Bass, Nicholas J, Young, Allan H, Lawrence, Jacob, Ferrier, I Nicol, Anjorin, Adebayo, Farmer, Anne, Curtis, David, Scolnick, Edward M, McGuffin, Peter, Daly, Mark J, Corvin, Aiden P, Holmans, Peter A, Blackwood, Douglas H, Gurling, Hugh M, Owen, Michael J, Purcell, Shaun M, Sklar, Pamela, Craddock, Nick
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703780/
https://ncbi.nlm.nih.gov/pubmed/18711365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.209
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