Pharmacokinetics and tumor dynamics of the nanoparticle IT-101 from PET imaging and tumor histological measurements

IT-101, a cyclodextrin polymer-based nanoparticle containing camptothecin, is in clinical development for the treatment of cancer. Multiorgan pharmacokinetics and accumulation in tumor tissue of IT-101 is investigated by using PET. IT-101 is modified through the attachment of a 1,4,7,10-tetraazacycl...

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Detalhes bibliográficos
Main Authors: Schluep, Thomas, Hwang, Jungyeon, Hildebrandt, Isabel J., Czernin, Johannes, Choi, Chung Hang J., Alabi, Christopher A., Mack, Brendan C., Davis, Mark E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703672/
https://ncbi.nlm.nih.gov/pubmed/19564622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905487106
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