Hypermethylation of Homeobox A10 by in Utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming

Diethylstilbestrol (DES) is a nonsteroidal estrogen that induces developmental anomalies of the female reproductive tract. The homeobox gene HOXA10 controls uterine organogenesis, and its expression is altered after in utero DES exposure. We hypothesized that an epigenetic mechanism underlies DES-me...

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Hlavní autoři: Bromer, Jason G., Wu, Jie, Zhou, Yuping, Taylor, Hugh S.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Endocrine Society 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703508/
https://ncbi.nlm.nih.gov/pubmed/19299448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-0071
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