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Synthetic Studies Towards the Mitomycins: Construction of the Tetracyclic Core via a Reductive Aminocyclization Reaction

The tetracyclic core of the mitomycin family of natural products has been formed in one step from an acyclic precursor via a reductive aminocyclization reaction. Additionally, the 8-membered benzazocine can be prepared without the need for prior activation of the aniline. Construction of a mitomycin...

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Detalhes bibliográficos
Main Authors: Gubler, Daniel A., Williams, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702872/
https://ncbi.nlm.nih.gov/pubmed/20161278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2009.05.004
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