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Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8(+) T cells

Paraneoplastic neurologic disorders (PNDs) offer an uncommon opportunity to study human tumor immunity and autoimmunity. In small cell lung cancer (SCLC), expression of the HuD neuronal antigen is thought to lead to immune recognition, suppression of tumor growth, and, in a subset of patients, trigg...

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Autori principali: Roberts, Wendy K., Deluca, Ilana J., Thomas, Ashby, Fak, John, Williams, Travis, Buckley, Noreen, Dousmanis, Athanasios G., Posner, Jerome B., Darnell, Robert B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701858/
https://ncbi.nlm.nih.gov/pubmed/19509467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36131
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