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Thiols oxidation and covalent binding of BSA by cyclolignanic quinones are enhanced by the magnesium cation
A novel cyclolignanic quinone, 7-acetyl-3′,4′-didemethoxy-3′,4′-dioxopodophyllotoxin (CLQ), inhibits topoisomerase II (TOPO II) activity. The extent of this inhibition was greater than that produced by the etoposide quinone (EQ) or etoposide. Glutathione (GSH) reduces EQ and CLQ to their correspondi...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701660/ https://ncbi.nlm.nih.gov/pubmed/18324525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10715760701790671 |
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