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Thiols oxidation and covalent binding of BSA by cyclolignanic quinones are enhanced by the magnesium cation
A novel cyclolignanic quinone, 7-acetyl-3′,4′-didemethoxy-3′,4′-dioxopodophyllotoxin (CLQ), inhibits topoisomerase II (TOPO II) activity. The extent of this inhibition was greater than that produced by the etoposide quinone (EQ) or etoposide. Glutathione (GSH) reduces EQ and CLQ to their correspondi...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701660/ https://ncbi.nlm.nih.gov/pubmed/18324525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10715760701790671 |
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