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L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism

Long Interspersed Element 1 (L1) is a retrotransposon that comprises ∼17% of the human genome. Despite its abundance in mammalian genomes, relatively little is understood about L1 retrotransposition in vivo. To study the timing and tissue specificity of retrotransposition, we created transgenic mous...

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Detalhes bibliográficos
Main Authors: Kano, Hiroki, Godoy, Irene, Courtney, Christine, Vetter, Melissa R., Gerton, George L., Ostertag, Eric M., Kazazian, Haig H.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701581/
https://ncbi.nlm.nih.gov/pubmed/19487571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1803909
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