L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism

Long Interspersed Element 1 (L1) is a retrotransposon that comprises ∼17% of the human genome. Despite its abundance in mammalian genomes, relatively little is understood about L1 retrotransposition in vivo. To study the timing and tissue specificity of retrotransposition, we created transgenic mous...

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Bibliografiske detaljer
Main Authors: Kano, Hiroki, Godoy, Irene, Courtney, Christine, Vetter, Melissa R., Gerton, George L., Ostertag, Eric M., Kazazian, Haig H.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2009
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701581/
https://ncbi.nlm.nih.gov/pubmed/19487571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1803909
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