S-Adenosylmethionine and Methylthioadenosine Inhibit Cellular FLICE Inhibitory Protein Expression and Induce Apoptosis in Colon Cancer Cells

S-Adenosylmethionine (SAMe) and its metabolite 5′-methylthioadenosine (MTA) inhibit mitogen-induced proliferative response in liver and colon cancer cells. SAMe and MTA are also proapoptotic in liver cancer cells by selectively inducing Bcl-x(S) expression. The aims of this work were to assess wheth...

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Main Authors: Li, Tony W. H., Zhang, Qingsong, Oh, Pilsoo, Xia, Meng, Chen, Hui, Bemanian, Sean, Lastra, Natalie, Circ, Magda, Moyer, Mary Pat, Mato, José M., Aw, Tak Yee, Lu, Shelly C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701463/
https://ncbi.nlm.nih.gov/pubmed/19372210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.054411
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