Inhibition of Aquaporin-1 and Aquaporin-4 Water Permeability by a Derivative of the Loop Diuretic Bumetanide Acting at an Internal Pore-Occluding Binding Site

Aquaporin (AQP) water channels, essential for fluid homeostasis, are expressed in perivascular brain end-feet regions of astroglia (AQP4) and in choroid plexus (AQP1). At a high concentration, the loop diuretic bumetanide has been shown to reduce rat brain edema after ischemic stroke by blocking Na(...

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Bibliografiske detaljer
Main Authors: Migliati, Elton, Meurice, Nathalie, DuBois, Pascale, Fang, Jennifer S., Somasekharan, Suma, Beckett, Elizabeth, Flynn, Gary, Yool, Andrea J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701455/
https://ncbi.nlm.nih.gov/pubmed/19403703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.053744
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