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Loop Diuretic and Ion-binding Residues Revealed by Scanning Mutagenesis of Transmembrane Helix 3 (TM3) of Na-K-Cl Cotransporter (NKCC1)

The Na-K-Cl cotransporter (NKCC) plays central roles in cellular chloride homeostasis and in epithelial salt transport, but to date little is known about the mechanism by which the transporter moves ions across the membrane. We examined the functional role of transmembrane helix 3 (TM3) in NKCC1 usi...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Somasekharan, Suma, Tanis, Jessica, Forbush, Biff
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366785/
https://ncbi.nlm.nih.gov/pubmed/22437837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.356014
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