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Probing nucleosome function: A highly versatile library of synthetic histone H3 and H4 mutants
Nucleosome structural integrity underlies the regulation of DNA metabolism and transcription. Using a synthetic approach, a versatile library of 486 systematic histone H3 and H4 substitution and deletion mutants was generated in Saccharomyces cerevisiae that probes the contribution of each residue t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701395/ https://ncbi.nlm.nih.gov/pubmed/18805098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.07.019 |
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