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Binding-site geometry and flexibility in DC-SIGN demonstrated with surface force measurements
The dendritic cell receptor DC-SIGN mediates pathogen recognition by binding to glycans characteristic of pathogen surfaces, including those found on HIV. Clustering of carbohydrate-binding sites in the receptor tetramer is believed to be critical for targeting of pathogen glycans, but the arrangeme...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701343/ https://ncbi.nlm.nih.gov/pubmed/19553201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901783106 |
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