Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function

Neurog3 (Neurogenin 3 or Ngn3) is both necessary and sufficient to induce endocrine islet cell differentiation from embryonic pancreatic progenitors. Since robust Neurog3 expression has not been detected in hormone-expressing cells, Neurog3 is used as an endocrine progenitor marker and regarded as d...

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Main Authors: Wang, Sui, Jensen, Jan N., Seymour, Philip A., Hsu, Wei, Dor, Yuval, Sander, Maike, Magnuson, Mark A., Serup, Palle, Gu, Guoqiang
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701002/
https://ncbi.nlm.nih.gov/pubmed/19487660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904247106
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