Two PEST-like motifs regulate Ca2+/calpain-mediated cleavage of the Ca(V)β(3) subunit and provide important determinants for neuronal Ca2+ channel activity

Increase in intracellular Ca(2+) due to voltage-gated Ca(2+) (Ca(V)) channel opening represents an important trigger for a number of second-messenger mediated effects ranging from neurotransmitter release to gene activation. Ca(2+) entry occurs through the principal pore-forming protein, but several...

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Main Authors: Sandoval, Alejandro, Oviedo, Norma, Tadmouri, Abir, Avila, Traudy, De Waard, Michel, Felix, Ricardo
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science 2006
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700823/
https://ncbi.nlm.nih.gov/pubmed/16706839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2006.04749.x
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