In vivo Efficacy of Marimastat and Chemoradiation in Head and Neck Cancer Xenografts

OBJECTIVE: To assess the effect of combining a synthetic matrix metalloprotease inhibitor and chemoradiation therapy on tumor growth in a murine model of head and neck squamous-cell carcinoma (SCC). METHODS: Athymic, nude mice bearing SCC-1 xenografts were used to comprise 4 treatment groups: (1) co...

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Hauptverfasser: Skipper, Joni B., McNally, Lacey R., Rosenthal, Eben L., Wang, Wenquan, Buchsbaum, Donald J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: S. Karger AG 2009
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700630/
https://ncbi.nlm.nih.gov/pubmed/18931526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000163217
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