Adenoviral expression of a transforming growth factor-β1 antisense mRNA is effective in preventing liver fibrosis in bile-duct ligated rats

BACKGROUND: Transforming growth factor-β (TGF-β) is a key mediator in establishing liver fibrosis. Therefore, TGF-β as a causative agent may serve as a primary target for antifibrotic gene therapy approaches. We have previously shown that the adenoviral delivery of a transgene constitutively express...

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Main Authors: Arias, Monica, Sauer-Lehnen, Sibille, Treptau, Jens, Janoschek, Nora, Theuerkauf, Ingo, Buettner, Reinhard, Gressner, Axel M, Weiskirchen, Ralf
Format: Artigo
Language:Inglês
Published: BioMed Central 2003
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC270053/
https://ncbi.nlm.nih.gov/pubmed/14565855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-230X-3-29
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