Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members

It is still unclear whether the BH3-only protein Puma (p53 up-regulated modulator of apoptosis) can prime cells to death and render antiapoptotic BH3-binding Bcl-2 homologues necessary for survival through its ability to directly interact with proapoptotic Bax and activate it. In this study, we prov...

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Detalhes bibliográficos
Main Authors: Gallenne, Tristan, Gautier, Fabien, Oliver, Lisa, Hervouet, Eric, Noël, Belinda, Hickman, John A., Geneste, Olivier, Cartron, Pierre-François, Vallette, François M., Manon, Stephen, Juin, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700382/
https://ncbi.nlm.nih.gov/pubmed/19380879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200809153
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