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Impaired development of human Th1 cells in patients with deficient expression of STAT4
IL-12 activates STAT4, which is a critical regulator of inflammation and T helper type I (Th1) lineage development in murine systems. The requirement for STAT4 in the generation of human Th1 cells has not been examined thoroughly. Compared with control Th1 cultures, expression of the Th1 genes IFNγ,...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2700324/ https://ncbi.nlm.nih.gov/pubmed/19359411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-179820 |
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