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Mre11-Rad50 Promotes Rapid Repair of DNA Damage in the Polyploid Archaeon Haloferax volcanii by Restraining Homologous Recombination

Polyploidy is frequent in nature and is a hallmark of cancer cells, but little is known about the strategy of DNA repair in polyploid organisms. We have studied DNA repair in the polyploid archaeon Haloferax volcanii, which contains up to 20 genome copies. We have focused on the role of Mre11 and Ra...

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Detalles Bibliográficos
Main Authors: Delmas, Stéphane, Shunburne, Lee, Ngo, Hien-Ping, Allers, Thorsten
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700283/
https://ncbi.nlm.nih.gov/pubmed/19593371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000552
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