Analysis of Pulmonary Vasodilator Responses to SB-772077-B [4-(7-((3-Amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a Novel Aminofurazan-Based Rho Kinase Inhibitor

The effects of SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], an aminofurazan-based Rho kinase inhibitor, on the pulmonary vascular bed and on monocrotaline-induced pulmonary hypertension were investigated in the rat. The intrave...

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Hlavní autoři: Dhaliwal, Jasdeep S., Badejo, Adeleke M., Casey, David B., Murthy, Subramanyam N., Kadowitz, Philip J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Pharmacology and Experimental Therapeutics 2009
Témata:
Cardiovascular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700172/
https://ncbi.nlm.nih.gov/pubmed/19369577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.151449
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