The Expression of Human Microsomal Epoxide Hydrolase Is Predominantly Driven by a Genetically Polymorphic Far Upstream Promoter

Microsomal epoxide hydrolase (EPHX1) biotransforms epoxide derivatives of pharmaceuticals, including metabolites of certain antiepileptic medications, such as phenytoin and carbamazepine, and many environmental epoxides, such as those derived from butadiene, benzene, and carcinogenic polyaromatic hy...

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Hlavní autoři: Yang, Xi, Liang, Shun-Hsin, Weyant, Denise M., Lazarus, Philip, Gallagher, Carla J., Omiecinski, Curtis J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Pharmacology and Experimental Therapeutics 2009
Témata:
Metabolism, Transport, and Pharmacogenomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700158/
https://ncbi.nlm.nih.gov/pubmed/19364907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.150870
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