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Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin
Adjustable control of therapeutic transgenes in engineered cell implants after transdermal and topical delivery of nontoxic trigger molecules would increase convenience, patient compliance, and elimination of hepatic first-pass effect in future therapies. Pseudomonas putida DOT-T1E has evolved the f...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2700147/ https://ncbi.nlm.nih.gov/pubmed/19549857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901501106 |
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