A synthetic mammalian gene circuit reveals antituberculosis compounds

Synthetic biology provides insight into natural gene-network dynamics and enables assembly of engineered transcription circuitries for production of difficult-to-access therapeutic molecules. In Mycobacterium tuberculosis EthR binds to a specific operator (O(ethR)) thereby repressing ethA and preven...

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Bibliographic Details
Main Authors: Weber, Wilfried, Schoenmakers, Ronald, Keller, Bettina, Gitzinger, Marc, Grau, Thomas, Daoud-El Baba, Marie, Sander, Peter, Fussenegger, Martin
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481315/
https://ncbi.nlm.nih.gov/pubmed/18621677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800663105
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