Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Expression

OBJECTIVE: The peroxisome proliferator–activated receptor-γ coactivator (PGC)-1 family of transcriptional coactivators controls hepatic function by modulating the expression of key metabolic enzymes. Hepatic gain of function and complete genetic ablation of PGC-1α show that this coactivator is impor...

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Main Authors: Estall, Jennifer L., Kahn, Mario, Cooper, Marcus P., Fisher, ffolliott Martin, Wu, Michele K., Laznik, Dina, Qu, Lishu, Cohen, David E., Shulman, Gerald I., Spiegelman, Bruce M.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2009
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699879/
https://ncbi.nlm.nih.gov/pubmed/19366863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1571
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