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Active site electrostatics protect genome integrity by blocking abortive hydrolysis during DNA recombination
Water, acting as a rogue nucleophile, can disrupt transesterification steps of important phosphoryl transfer reactions in DNA and RNA. We have unveiled this risk, and identified safeguards instituted against it, during strand cleavage and joining by the tyrosine site-specific recombinase Flp. Strand...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699359/ https://ncbi.nlm.nih.gov/pubmed/19440204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.131 |
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