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Anti-CTLA4 Antibody Clinical Trials in Melanoma
The cytotoxic T lymphocyte-associated protein 4 (CTLA4) is a main negative regulator of the immune system, which inhibits the costimulatory signaling for T cells. Preclinical studies demonstrated that antibodies against CTLA4 induced regression of some murine tumors. Two CTLA4 blocking monoclonal an...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699286/ https://ncbi.nlm.nih.gov/pubmed/19543441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.uct.2007.09.001 |
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