Rational combined targeting of phosphodiesterase 4B and SYK in DLBCL

Identification of rational therapeutic targets is an important strategy to improve the cure rate of diffuse large B-cell lymphoma (DLBCL). We previously showed that inhibition of the phosphodiesterase 4B (PDE4B) unleashes cyclic-AMP (cAMP) inhibitory effects toward the PI3K/AKT pathway and induces a...

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Hlavní autoři: Kim, Sang-Woo, Rai, Deepak, McKeller, Morgan R., Aguiar, Ricardo C. T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2009
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699235/
https://ncbi.nlm.nih.gov/pubmed/19369227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-206128
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