Akt regulates L-type Ca(2+) channel activity by modulating Ca(v)α1 protein stability

The insulin IGF-1–PI3K–Akt signaling pathway has been suggested to improve cardiac inotropism and increase Ca(2+) handling through the effects of the protein kinase Akt. However, the underlying molecular mechanisms remain largely unknown. In this study, we provide evidence for an unanticipated regul...

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Detalhes bibliográficos
Main Authors: Catalucci, Daniele, Zhang, Deng-Hong, DeSantiago, Jaime, Aimond, Franck, Barbara, Guillaume, Chemin, Jean, Bonci, Désiré, Picht, Eckard, Rusconi, Francesca, Dalton, Nancy D., Peterson, Kirk L., Richard, Sylvain, Bers, Donald M., Brown, Joan Heller, Condorelli, Gianluigi
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699149/
https://ncbi.nlm.nih.gov/pubmed/19307602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200805063
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