Akt regulates L-type Ca(2+) channel activity by modulating Ca(v)α1 protein stability

The insulin IGF-1–PI3K–Akt signaling pathway has been suggested to improve cardiac inotropism and increase Ca(2+) handling through the effects of the protein kinase Akt. However, the underlying molecular mechanisms remain largely unknown. In this study, we provide evidence for an unanticipated regul...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Catalucci, Daniele, Zhang, Deng-Hong, DeSantiago, Jaime, Aimond, Franck, Barbara, Guillaume, Chemin, Jean, Bonci, Désiré, Picht, Eckard, Rusconi, Francesca, Dalton, Nancy D., Peterson, Kirk L., Richard, Sylvain, Bers, Donald M., Brown, Joan Heller, Condorelli, Gianluigi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2009
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699149/
https://ncbi.nlm.nih.gov/pubmed/19307602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200805063
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