Glucocorticoid receptor mRNA levels are selectively decreased in neutrophils of children with sepsis

OBJECTIVE: Corticosteroids are used in sepsis treatment to benefit outcome. However, discussion remains on which patients will benefit from treatment. Inter-individual variations in cortisol sensitivity, mediated through the glucocorticoid receptor, might play a role in the observed differences. Our...

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Main Authors: van den Akker, Erica L. T., Koper, Jan W., Joosten, Koen, de Jong, Frank H., Hazelzet, Jan A., Lamberts, Steven W. J., Hokken-Koelega, Anita C. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2009
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Original
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698978/
https://ncbi.nlm.nih.gov/pubmed/19373457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00134-009-1468-6
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