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Derivation of induced pluripotent stem cells from pig somatic cells

For reasons that are unclear the production of embryonic stem cells from ungulates has proved elusive. Here, we describe induced pluripotent stem cells (iPSC) derived from porcine fetal fibroblasts by lentiviral transduction of 4 human (h) genes, hOCT4, hSOX2, hKLF4, and hc-MYC, the combination comm...

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Détails bibliographiques
Auteurs principaux: Ezashi, Toshihiko, Telugu, Bhanu Prakash V. L., Alexenko, Andrei P., Sachdev, Shrikesh, Sinha, Sunilima, Roberts, R. Michael
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698893/
https://ncbi.nlm.nih.gov/pubmed/19541600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905284106
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